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Master 2 Project: Development of chemical and bioprobes selective to persistant organic pollutants


Vacancy details

General information

Organisation

The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.

Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.

The CEA is established in ten centers spread throughout France
  

Reference

2019-11435  

Description de l'unité

L'Unité Mixte de Recherche Génomique Métabolique (UMR GM) conduit des projets pluridisciplinaires de recherche fondamentale et appliquée, qui s'appuient sur des compétences clés en bio-informatique, biocatalyse, biologie moléculaire, biochimie, biologie synthétique, métabolomique et chimie environnementale. Au sein de l'UMR GM, un projet associant plusieurs équipes et portant sur la biodégradation de la chlordécone est développé depuis une dizaine d'années. Un certain nombre de bactéries induisant la transformation de la chlordécone ont été isolées. Les nombreux produits de transformation ont été identifiés en laboratoire puis détectés aux Antilles. Ces résultats récents démontrent que cette molécule réputée non dégradable dans l'environnement pouvait en fait être transformée naturellement ce qui ouvre la voie à une possible bioremédiation. Le Genoscope auquel est rattaché l'Unité Mixte de Recherche, rassemble une centaine de salariés permanents et une cinquantaine de salariés non permanents (CDD, doctorants, post-doctorants, stagiaires). Il est implanté sur la Génopole d'Evry (91), 30 km au sud de Paris.

Position description

Category

Chemistry

Contract

Internship

Job title

Master 2 Project: Development of chemical and bioprobes selective to persistant organic pollutants

Subject

Development of chemical and bioprobes against the perfluoroalkyl chains common to all per- and polyfluoroalkyl substances as well as the perchlorinated bishomocubane cage-structure characteristic of the pesticides chlordecone and mirex would represent attractive alternatives to standard mass-spectrometry techniques. The research project aims at synthesizing PFAS and chlordecone/mirex derivatives grafted onto solid supports in order to screen chemicals and biomolecules for their capacity to recognize these peculiar chemical motifs through covalent and/or non-covalent interactions.

Contract duration (months)

6

Job description

Among the numerous persistant organic pollutants, we are working on the environmental fate of chlordecone, mirex and the per- and polyfluoroalkyl substances (PFAS). Use of chlordecone has caused long-term environmental pollution, from decades to centuries in the French West Indies that results in acute human-health problems and a social crisis. PFAS appear as an emerging class of pollutants that chemical companies continuously expand to overcome regulation modifications that have restricted and even forbidden the use of certain congeners.

Development of chemical and bioprobes against the perfluoroalkyl chains common to all PFAS as well as the perchlorinated bishomocubane cage-structure characteristic of chlordecone and mirex would represent attractive alternatives to standard mass-spectrometry techniques. This research project aims at synthesizing PFAS and chlordecone/mirex derivatives grafted onto solid supports in order to screen chemicals and biomolecules (eg single stranded-DNA aptamers, antibodies) for their capacity to recognize these peculiar chemical motifs through covalent and/or non-covalent interactions.
Among the numerous persistant organic pollutants, we are working on the environmental fate of chlordecone, mirex and the per- and polyfluoroalkyl substances (PFAS). Use of chlordecone has caused long-term environmental pollution, from decades to centuries in the French West Indies that results in acute human-health problems and a social crisis. PFAS appear as an emerging class of pollutants that chemical companies continuously expand to overcome regulation modifications that have restricted and even forbidden the use of certain congeners.

Development of chemical and bioprobes against the perfluoroalkyl chains common to all PFAS as well as the perchlorinated bishomocubane cage-structure characteristic of chlordecone and mirex would represent attractive alternatives to standard mass-spectrometry techniques. The research project aims at synthesizing PFAS and chlordecone/mirex derivatives grafted onto solid supports in order to screen chemicals and biomolecules (eg single stranded-DNA aptamers, antibodies) for their capacity to recognize these peculiar chemical motifs through covalent and/or non-covalent interactions.

Methods / Means

Organic Synthesis, analytical techniques (GC-MS and LC-MS), Selex Technique for DNA selection

Applicant Profile

Student in chemistry (Ingenieur or University) possessing a strong background in organic chemistry including experimental practice in research lab. Experience with GC-MS and/or LC-MS equipment would be also strongly appreciated. A high interest for environmental topics and a motivation to work and develop skills at the chemistry-biology interface are essential for the success of the internship.

Position localisation

Site

Other

Job location

France, Ile-de-France, Essonne (91)

Location

Evry

Candidate criteria

Prepared diploma

Bac+5 - Diplôme École d'ingénieurs

Recommended training

organic chemistry with lab experience required

Requester

Position start date

17/02/2020