Can the mechanical environment of neurons influence their response to light? 

Photobiomodulation (PBM) is an emerging non pharmacological therapeutic approach using light to modulate cellular functions, with promising applications in neuroscience. However, its mechanisms of action remain incompletely understood.

Neuronal behaviour is strongly influenced by the mechanical properties of the surrounding microenvironment, a factor often overlooked in conventional in vitro models. Could substrate stiffness influence neuronal responses to PBM and reveal new insights into its cellular mechanisms?

This internship aims to develop and characterise a biomimetic neuronal culture system using soft substrates with controlled mechanical properties to investigate how the mechanical microenvironment modulates PBM effects. You will contribute to:
- Developing and characterising biomimetic soft substrates and establishing neuronal cultures.
- Investigating the influence of substrate stiffness on neuronal behaviour and responses to PBM.
- Exploring the underlying cellular mechanisms using a dedicated PBM illumination setup integrated into a cell culture incubator.

Why join us?
Join a multidisciplinary research team at CEA-Leti, in collaboration with CNRS LTM, and explore an original scientific question at the crossroads of neuroscience, cellular biomechanics and light based therapies.

This internship offers hands-on experience in an innovative research field, with potential implications for future neuroprotective strategies and the possibility of continuing towards a PhD, subject to project development and funding.

Who are we looking for?
A curious and motivated Master 2 student with a background in cell biology, molecular biology, cellular physiology, biophysics or a related discipline.

An interest in neuroscience and interdisciplinary experimental research will be particularly appreciated.