General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
2024-31575
Division description
CEA-Leti is a recognized global leader in miniaturization technologies.
CEA-Leti's teams are focused on developing solutions that will enable future information and communication technologies, health and wellness approaches, clean and safe energy production and recovery, sustainable transport, space exploration and cybersecurity.
Description de l'unité
Within CEA-Leti, the Department of Technologies for Health Innovation operates in the field of microtechnologies to adress societal challenges in biology and healthcare, with a 'One health' approach that considers the interconnected domains of human, animal and environmental health.
Position description
Category
Health
Contract
Fixed-term contract
Job title
Development of a microfluidic architecture for the production of lipid nanoparticles
Socio-professional category
Executive
Contract duration (months)
18
Job description
This project, in partnership with an industrial company, aims to develop a new production concept in microfluidic cards for preparing therapeutics based on lipid nanoparticles (LNPs/mRNA).
LNPs production is achieved through the rapid mixing of two fluids, one lipid based and the other aqueous, within a microfluidic architecture The characteristics of LNPs depend closely on the quality and speed of micromixing.
Mission
Your mission will involve proposing, designing, and testing microfluidic architectures for production of lipid nanoparticles in accordance with the client's specifications.
Your contribution will leverage the team's expertise in flow control, microfluidic architecture integration, and instrumentation to progressively master the entire process of lipid nanoparticle production.
Tasks Required
We are seeking a researcher/engineer with prior experience in microfluidics You will be responsible for designing and drawing microfluidic architectures, testing and optimizing them You will oversee the setup of experimental benches, as well as the optimization and validation of processes.
Additionally, you will lead the evolution of the benches towards an automated nanoparticle production prototype.
You will collaborate with specialized teams in microfluidics, chemistry, and biology, serving as the interface between them.
Furthermore, you will be required to write reports in English, present your work to the team, and participate in laboratory and project meetings (including oral and written communications).
Applicant Profile
Your educational background may include physics, engineering, fluid mechanics, bioengineering with a particular affinity for experimental approaches.
Prior experience in microfluidics/lab-on-chip is necessary, and experience in lipid nanoparticles production would be advantageous.
Fluency in French and/or English and strong communication skills are required as you will frequently report your results to the entire project team.
You should be highly motivated to be part of a dynamic and multidisciplinary project in an advanced environment.
The candidate must have been vaccinated against hepatitis B.
Position location
Site
Grenoble
Job location
France, Auvergne-Rhône-Alpes, Isère (38)
Location
Grenoble
Candidate criteria
Languages
English (Intermediate)
Requester
Position start date
01/05/2024
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