Are you passionate about the enzymatic reactions of anaerobic microbes and keen to contribute to excellence in scientific research? Join us as a PhD student on a three-year fixed-term contract and be part of the IBS/IRIG Institute!

The position is available to investigate the enzymatic chemistry orchestrated in the microbial anaerobic carbon cycling. The offer is part of the ERC Project “EnLightEn,” which is devoted to understanding the molecular basis of methanogenesis and methanotrophy in non-isolated anaerobic archaea. The position will be hosted in the newly established Microbial Metabolism team, with a preferred starting date of late summer 2026. 

Your tasks will include:

• Extract the native proteins involved in catabolic processes and purify them using our oxygen-free method
• Characterize them using biochemical, biophysical, and structural tools
• Develop reaction assays to confirm and quantify enzymatic activity
• Analyze the data obtained to elucidate reaction mechanisms
• Present and publish these findings in scientific articles. 

This unconventional approach, which circumvents the barrier posed by microbial isolation, enables us to understand the molecular mechanisms of native enzymes involved in the conversion of carbon-based molecules, with potential applications in industrial chemistry. EnLightEn will open up a new field of research to characterise functional dark matter, which can then be applied to other metabolic processes and offer an unprecedented insight into the molecular tricks employed by the microbial world.

The ideal candidate is a protein biochemist with a background in chemistry and a strong interest in exploring Life´s catalysts. The candidate must hold a master's degree in biochemistry and preferably have experience purifying native proteins, setting up enzymatic assays, and protein biophysical/biochemical characterization. Applicants with skills in anaerobic handling (e.g., anaerobic protein purification, assays…), analyses of enzymatic reaction mechanisms, and structural biology will be prioritized.

You will need to demonstrate an open mind and a high degree of scientific rigour. You must be fluent in English, which will enable you to communicate effectively with the team and write scientific articles.

🤝 Why join us? ….

By joining the Grenoble Interdisciplinary Institute, you’ll be part of a dynamic and innovative research environment where you’ll have the opportunity to learn, grow and play a key role within a centre of excellence.

…AND THAT’S NOT ALL!

You may be interested in the benefits that come alongside your main role:

A cutting-edge research ecosystem dedicated to topics of significant societal importance.
Training to enhance your skills and boost your career.
A staff committee offering a wealth of social, cultural and sporting benefits.
Practical benefits: staff canteen/meal vouchers, 85% of transport costs covered, and much more.
An exceptional living environment in Grenoble, nestled in the mountains, offering a unique balance between city life and nature.
🚀 Want to be part of the adventure? Apply now and put your energy to work for research and innovation!

In line with the CEA’s commitments to the integration of people with disabilities, this role is open to everyone. The CEA offers adjustments and/or organisational arrangements to facilitate the inclusion of disabled workers