Informations générales
Entité de rattachement
Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.
Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs.
Implanté au cœur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international.
Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales :
• La conscience des responsabilités
• La coopération
• La curiosité
Référence
2025-36530
Description de l'unité
The Interdisciplinary Research Institute of Grenoble (IRIG), created on January 1st, 2019, conducts research in biology, health, nanosciences, cryo-technologies and new technologies for energy and the environment. Physicists, chemists, biologists, physicians, computer scientists and mathematicians participate jointly in this fundamental research and the applications that result from it, giving the institute a remarkable capacity to respond to major societal challenges.
Description du poste
Domaine
Biologie, biophysique et biochimie
Contrat
Post-doctorat
Intitulé de l'offre
Post-doctoral fellow in cell biology / biotechnology field H/F
Sujet de stage
Islet transplantation graft follow-up on-chip for type 1 diabetes.
Durée du contrat (en mois)
24
Description de l'offre
Laboratory: BIOMICS LAB, IRIG, CEA Grenoble (UGA/Inserm/CEA), 17 avenue des Martyrs, 38 054 Grenoble, France. Head of lab: Xavier Gidrol.
Project context: Diabetes is a growing threat to global health, affecting 463 million people worldwide in 2019, or 1 in 11 adults. The World Health Organization predicts that 578 million people will suffer from diabetes in 2030. Diabetes, type 1 or 2, cause an abnormal and prolonged increase of the blood glucose level, mainly caused by deficiency or failure to use insulin. In the long term, diabetes can lead to many complications, including vasculopathy, neuropathy, retinopathy, and diabetic foot ulcer.
Cell replacement therapy is possible for some patients, called pancreatic islet transplantation, which has recently been accepted into routine care by the French “Haute Autorité de Santé”. Despite the effectiveness of this therapy some weaknesses remain, highlighting the need to have a relevant human model, to understand the decline of pancreatic islets transplant in order to finely-tune the treatment for each grafted patient.
In this context, we aim at personalized medicine for T1D patients’ ongoing pancreatic islet transplantation.
Project description: This candidate will be using native human islets and be focused on the cryopreservation of native islets, be involved in islet-on-chip experiments (with a PhD student), and will focus on immunity assessment with the patient’s samples, to answer the personalized medicine challenges. The candidate will work closely with our research team and collaborate with our partners (CEA Leti, CHU Grenoble).
The candidate will perform cell culture and cryopreservation, microfluidics, transcriptomics analysis, image analysis and quantification.
In line with CEA's commitment to the integration of disabled people, this job is open to all. The CEA offers accommodation and/or organisational possibilities for the inclusion of disabled workers
Profil du candidat
• Highly motivated, enthusiast and curious,
• Background in cell biology, primary cell culture, molecular biology, or a related field,
• Background in image analysis and quantification (Imaris for eg)
• Experience in cryopreservation would be a plus,
• Background in bioinformatics and transcriptomics analysis would be a plus,
• Strong analytical and organizational skills,
• Ability to work independently and as part of a team,
• Good ability to interact with people.
Localisation du poste
Site
Grenoble
Localisation du poste
France, Auvergne-Rhône-Alpes, Isère (38)
Ville
Grenoble
Critères candidat
Formation recommandée
PhD
Possibilité de poursuite en thèse
Non
Demandeur
Disponibilité du poste
01/12/2025
Je me crée un espace candidat
